Molecular determinants of arterial stiffness

Determinants of arterial stiffness in COPD

BACKGROUND Cardiovascular morbidity and mortality is high in patients with chronic obstructive pulmonary disease (COPD) and arterial stiffness is a potentially modifiable risk factor with added predictive value beyond that obtained from traditional risk factors. Arterial stiffness has been the target of pharmacologic and exercise interventions in patients with COPD, but the effects appear limit...

Ambulatory arterial stiffness index: determinants and outcome.

OBJECTIVES We hypothesized that one minus the slope of diastolic on systolic blood pressure in individual 24-h ambulatory blood pressure recordings (ambulatory arterial stiffness index) might reflect arterial stiffness and predict cardiovascular mortality. METHODS In volunteers and a population recruited in China, we studied concordance between ambulatory arterial stiffness index and establis...

Determinants of the ambulatory arterial stiffness index regression line.

Determinants of Arterial Stiffness in Chronic Kidney Disease Stage 3

BACKGROUND Early chronic kidney disease (CKD) is associated with increased cardiovascular (CV) risk but underlying mechanisms remain uncertain. Arterial stiffness (AS) is associated with increased CV risk in advanced CKD, but it is unclear whether AS is relevant to CV disease (CVD) in early CKD. STUDY DESIGN Cross-sectional. SETTING AND PARTICIPANTS 1717 patients with previous estimated glo...

Arterial Stiffness in the Young: Assessment, Determinants, and Implications

Arterial stiffness describes the rigidity of the arterial wall. Its significance owes to its relationship with the pulsatile afterload presented to the left ventricle and its implications on ventricular-arterial coupling. In adults, the contention that arterial stiffness as a marker and risk factor for cardiovascular morbidity and mortality is gaining support. Noninvasive methods have increasin...